Darwinism is shown possible to generalize fruitfully to help comprehend economic change by drawing on evolutionary developmental biology (“evo-devo”) – its recent version, less concerned with replication of genes than with genomic instructing of development of organisms. The result is a conceptual model with multilevel applications, generalizing development as instructed self-organizing with inputs from environments, and evolution as experimental search for instructions making the development successful. Its economic interpretation suggests to unite several existing fields into evolutionary developmental economics, where economic change can be studied comprehensively as development instructed by actual institutional rules, intertwined with the evolution of these rules.